Working with solitary-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic aspects of the framework and dynamics of chromosomes. Our investigation interests involve:
Human Rad51 filaments on double- and solitary-stranded DNA: correlating regular and irregular kinds with recombination function.
[Laughs] ‘It absolutely was surely an incredible possibility! At enough time, I used to be effectively conscious that it could go Incorrect and that I could develop into a lot less effective, but I just ignored that. Curiosity has always been my strongest driving pressure. And by chance all of it worked out.’
Sculpting nano-electrodes which has a transmission electron beam for electrical and geometrical characterization of nanoparticles.
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Microbiology has only existed for a century, because we started to research micro-organisms a lot more significantly. I believed nanobiology was an ideal expression, for the reason that all molecular Organic applicable interactions happen on the nanoscale: a protein is a number of nanometres in measurement, DNA is 2 nm thick.’
‘Initially we checked out Organic methods by using a Actual physical see and acted on The idea with the tools we knew. It took a several years right before we began Functioning additional on the big biological troubles. I then began to connect with it nanobiology, a term that did not exist at time.
Nanopores depict a chic and adaptable Device to measure single molecules. We investigate novel detection modes with reliable-condition nanopores and also a variety of solutions to evaluate proteins with nanopores. Assignments encompass the next:
2003, demonstrated the initial biosensors produced out of a carbon nanotube; fixed the framework and mechanism of DNA restore proteins; and discovery of a brand new technique for fabricating good-condition nanopores for DNA translocation
one). The present–voltage curves confirmed important modulations with gate voltage, even at room temperature, which was per band bending inside a ~0.six eV bandgap semiconducting nanotube. These data also showed which the conductance could possibly be modulated by 6 orders of magnitude by altering the gate voltage. The final results of this operate — a room-temperature transistor made out of a single carbon nanotube molecule — have been posted in Nature in May possibly 1998.
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1999, initially measurement from the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for the new Luttinger description of interacting electrons in nanotubes
2005, discovery of the mechanism of DNA uncoiling by ceesdekker topoisomerase enzymes; discovery of extensive-assortment conformational variations in Mre11/DNA mend complexes; and to start with power measurements over a DNA molecule in a nanopore
‘I am driven by surprise and inquiries. On a cloth amount I find answers in physics, but I expertise my deepest pleasure with God. That religion also drives my science And just how I contend with people.